Police later cordoned off the crime scene as onlookers crowded around the church, while a forensics team combed the area.Friday's attack came ahead of Christmas for the Copts, who celebrate it on January 7.
ISIS in Egypt has killed dozens of Christians in church bombings and shootings over the past year, and has threatened further attacks against the minority.
Samir Gerges, a witness, said people inside the church closed the gates when the shootout began but bullets from the gunfire still entered the building.
May 26: Masked gunmen order Christians travelling to a desert monastery to get off their buses and recant their faith.
The group - a mix of visitors and workers heading to the Saint Samuel monastery south of Cairo - refuse and are shot one by one. ISIS claims responsibility.- April 9: Two churches are bombed on Palm Sunday, killing 45 people.
When Jehovah's Witnesses produce scholars that support the NWT, we must first establish that the scholar is, indeed, a recognized expert in the field of Biblical Languages, and that he or she has been quoted accurately.